Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| Y642F | UPC2 | C. albicans | Validated | qRT-PCR, Ergosterol quantification | 22923048 25385095 |
Y642F mutation in UPC2 enhances ERG11 expression, increasing ergosterol synthesis and fluconazole resistance. | 2 |