Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| Y584C | PDR1 | C. glabrata | Validated | Gene Expression Analysis; Reconstitution Experiments; Isogenic Strains; In-vivo studies | 19148266 27020939 |
The gain-of-function Y584C mutation leads to the constitutive upregulation of the ABC-transporter gene CgCDR1, resulting in increased azole resistance | 2 |