Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| Y447H | ERG11 | C. albicans | Validated | Site-directed mutagenesis in P. Pastoris, sterol composition | 21698128 |
Y447H alters the ERG11 insertion loop, reducing fluconazole binding affinity and conferring resistance | 2 |