Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| Y372C | PDR1 | C. glabrata | Validated | Transcriptomic Analysis; Transcriptional Control | 30348666 |
The gain-of-function Y372C mutation upregulates CgCdr1 and CgCdr2, enhancing drug efflux, reducing intracellular drug levels, and conferring azole resistance. | 2 |