Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| Y141H | ERG11 | C. glabrata | Validated | Sterol Analysis | 30455247 |
The Y141H mutation in ERG11 reduces sterol 14-demethylase activity, leading to lanosterol accumulation and azole resistance. | 2 |