Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| Y132H | ERG11 | C. albicans | Validated | Homology modeling; Heterologous expression in Saccharomyces cerevisiae; Structural Modeling; Site-directed Mutagenesis | 9527767 10223930 15388421 15155210 25398256 34060660 36274705 |
Y132H mutation alters the structure of the ERG11 enzyme, reducing its affinity for fluconazole and leading to drug resistance | 2 |