Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| Y132F | ERG11 | C. tropicalis | Validated | mRNA extraction; qRT-PCR; Homology Modeling; Site-Directed Mutagenesis; Heterologous expression in Saccharomyces cerevisiae | 16251302 23877676 25398256 30472420 33123116 34604110 35819969 36274705 36135621 36294562 37159900 |
Y132F mutation alters the structure of the ERG11 enzyme, reducing its affinity for fluconazole and leading to drug resistance | 2 |