Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| Y132F | ERG11 | C. albicans | Validated | qRT-PCR; Immunoblotting; Site-directed mutagenesis; In vivo model; Gene efflux analysis | 15380275 16201925 20876623 23480635 24051054 25385095 25748216 |
Y132F mutation alters the structure of the ERG11 enzyme, reducing its affinity for fluconazole and leading to drug resistance | 2 |