Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| W986L | ZCF29 | C. albicans | Validated | qRt-PCR | 32179530 |
W986L mutation upregulates efflux pumps (CDR11, SNQ2, MDR1), reducing intracellular drug levels and conferring resistance to manogepix and beauvericin. | 2 |