Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| W893R | MRR1 | C. albicans | Validated | C. albicans transformation, site-directed mutagenesis, southern hybridization | 18577180 |
Gain of function mutation W893R leads to constitutive MDR1 overexpression, enhancing drug efflux and conferring azole resistance. | 2 |