Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| W297S | PDR1 | C. glabrata | Validated | Gene substitution; Northern blot analysis | 16569856 20547810 |
The W297S mutation increases fluconazole resistance by upregulating CgPDR1 and CgCDR1 expression. | 2 |