Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| W182stop | ERG3 | C. auris | Validated | Allele-specific PCR | 33820824 |
W182stop mutation disrupts sterol D5,6-desaturase function, preventing toxic sterol accumulation when ERG11 is inhibited, leading to cross-resistance to azoles and amphotericin B. | 2 |