Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| W1375L | FKS2 | C. glabrata | Validated | Gene Expression Profiling; Kinetic Analyses; 1,3-β-D-Glucan Synthase Inhibition Assays | 19546367 |
The W1375L mutation in FKS2 alters 1,3-β-D-glucan synthase conformation, reducing echinocandin binding and catalytic activity, leading to resistance. | 2 |