Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| W1358S | FKS1 | C. albicans | Validated | Chitin estimation, Biofilm formation assay, Murine model | 30794951 |
W1358S mutation alters 1,3-β-glucan synthase, conferring resistance while increased chitin strengthens the cell wall but decreases biofilm formation and virulence. | 2 |