Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| T896I | MRR1 | C. albicans | Validated | Introduction of Mutated Alleles into Drug-Susceptible Strains | 18577180 |
The T896I mutation constitutively activates Mrr1p, overexpressing the MDR1 efflux pump and promoting multidrug resistance. | 2 |