Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| T540I | CDR1 | C. albicans | Validated | Efflux Activity Assay; Growth Inhibition Assay | 30348662 |
The T540I mutation in Cdr1 alters transporter conformation and enabling co-transport of FK506 with other substrates, conferring resistance. | 2 |