Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| T386I | MRR2 | C. albicans | Validated | Gene expression | 31705810 |
The T386I mutation in Mrr2 increases the expression of Cdr1, enhancing efflux pump activity and reducing intracellular drug concentration, thereby contributing to FCA resistance in C. albicans. | 2 |