Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| T381I | MRR1 | C. albicans | Validated | Introduction of Mutated Alleles into Drug-Susceptible Strains | 18577180 |
The T381I mutation in the MRR1 gene causes constitutive activation of the Mrr1p transcription factor, leading to continuous overexpression of the MDR1 efflux pump and increased drug efflux, resulting in multidrug resistance, particularly to fluconazole. | 2 |