Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| T225A | TAC1 | C. albicans | Validated | Site-Directed Mutagenesis; Murine model | 17693596 24051054 |
The T225A mutation in TAC1 disrupts the transcriptional inhibitory domain, leading to hyperactivity of the TAC1 allele and increased expression of drug resistance genes, thereby contributing to azole resistance (PMID: 17693596) | 2 |