Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| T123I | ERG11 | C. albicans | Validated | RT-PCR | 29136186 27976986 31923309 |
The T123I mutation in the ERG11 gene alters the enzyme's active site structure, reducing azole binding affinity, and impairing drug efficacy, leading to resistance. | 2 |