Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| S542L | CDR1 | C. albicans | Validated | Efflux Activity Assay; Growth Inhibition Assay | 30348662 |
The S542L mutation in Cdr1, located in extracellular loop 1 (EL1), reduces FK506 sensitivity by altering the transporter’s conformation and enabling co-transport of FK506 with other substrates. | 2 |