Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| S480P | MRR2 | C. albicans | Validated | Gene expression | 31705810 |
The S480P mutation in Mrr2 increases the expression of multidrug efflux pump Cdr1, leading to enhanced drug efflux and reduced intracellular drug concentrations, conferring resistance. | 2 |