Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| S466L | MRR2 | C. albicans | Validated | qRT-PCR; Site-Directed Mutagenesis | 26404130 |
The S466L mutation in MRR1 enhances drug resistance by increasing CDR1 expression, which leads to a four-fold increase in fluconazole resistance | 2 |