Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| S405F | ERG11 | C. albicans | Validated | Subcellular Sterol Biosynthesis Assay;Homology modeling; PCR amplification; Northern blot analysis | 10537192 10537193 11557454 15155210 15388421 16201925 17693596 20876623 24051054 |
The S405F mutation in Erg11p alters the azole-binding pocket, reducing drug affinity and inhibiting effective ergosterol biosynthesis disruption, leading to azole resistance. | 2 |