Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| S391L | PDR1 | C. glabrata | Validated | qRT-PCR | 20547810 35577042 |
S391L is a gain-of-function mutation that enhances CgPdr1p, upregulating CgCDR1 and PDH1, increasing efflux pump expression, conferring resistance | 2 |