Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| S218P | ERG3 | C. kefyr | Validated | Sterol analyses using gas chromatography | 37358415 |
The S218P mutation in ERG3 disrupts its protein function, leading to the accumulation of ergosta-7,22-dienol, episterol [ergosta-7,24(28)-dienol] and ergosta-8,22-dienol and resulting in amphotericin B resistance. | 2 |