Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| R546Y | CDR1 | C. albicans | Validated | Efflux Activity Assay; Growth Inhibition Assay | 30348662 |
R546Y confers resistance by altering Cdr1's intramolecular contacts, preventing transporter inhibition | 2 |