Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| R546T | CDR1 | C. albicans | Validated | Efflux Activity Assay; Growth Inhibition Assay | 30348662 |
The R546T mutation reduces FK506 sensitivity by altering transporter conformation, enabling FK506 co-transport while maintaining efflux activity and lowering ATPase activity. | 2 |