Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| R469K | ERG11 | C. albicans | Validated | Restriction Enzyme Analysis (REA) | 19732347 |
The R469K mutation alters the cysteine pocket conformation in the third hot-spot region, disrupting inhibitor access and redox potential, leading to fluconazole resistance. | 2 |