Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| R467K | ERG11 | C. albicans | Validated | RT-PCR; Site-directed mutagenesis | 14688046 17693596 20367978 9527767 |
The R467K mutation reduces fluconazole binding affinity, and when combined with Y132H, it destabilizes the smaller, hydrophilic fluconazole molecule within the active pocket. | 2 |