Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| R365G | ERG3 | C. albicans | Validated | Gene expression analysis | 29136186 |
The R365G mutation impairs sterol Δ5,6-desaturase activity, leading to the accumulation of 14α-methylfecosterol, contributing to azole resistance. | 2 |