Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| R157K | ERG11 | C. albicans | Validated | Structural Analysis | 31923309 |
The R157K mutation reduces azole binding affinity, impairing enzyme inhibition and allowing continued ergosterol production, conferring resistance. | 2 |