Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| R1361H | FKS1 | C. glabrata | Validated | Expression profiling | 18955538 |
The R1361H mutation in FKS1 alters the β-1,3-glucan synthase target, reducing echinocandin binding efficiency and conferring resistance. | 2 |