Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| R1354S | FKS1 | C. auris | Validated | Murine model, Chitin content and gene expression analysis | 34780273 |
R1354S mutation alters 1,3-β-D-glucan synthase, reducing its susceptibility and contributing to echinocandin resistance. | 2 |