Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| Q350L | MRR1 | C. albicans | Validated | Competitive fitness assays; MDR1 promoter activity assay | 18577180 28461316 |
The Q350L mutation in MRR1 is a gain-of-function mutation that causes overexpression of the MDR1 efflux pump, contributing to fluconazole resistance (PMID: 18577180; 28461316) | 2 |