Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| Q1388P | CDR1 | C. albicans | Validated | Efflux Activity Assay; Growth Inhibition Assay | 30348662 |
The Q1388P mutation modifies intramolecular contact points, enabling co-transport of FK506 with other substrates conferring resistance. | 2 |