Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| P971S | TAC1 | C. albicans | Validated | Flow Cytometry; Murine model; RT-PCR | 31923309 |
The gain-of-function P971S mutation leads overproduction of efflux pumps CDR1 and CDR2, which lowers intracellular azole concentrations, conferring azole resistance. | 2 |