Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| P683H | MRR1 | C. albicans | Validated | Introduction of Mutated Alleles into Drug-Susceptible Strains | 18577180 |
The gain-of-function P683H mutation alters the transcription factor's activity, leading to the upregulation of MDR1 and contributing to multidrug resistance. | 2 |