Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| P649L | FKS1 | C. albicans | Validated | Murine model | 24733467 |
The P649L mutation in FKS1, reduces echinocandin binding by altering the structure of the glucan synthase complex causing resistance. | 2 |