Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| P633T | FKS2 | C. glabrata | Validated | Kinetic analyses | 18443110 |
P633T mutation alters the structure of 1,3-β-D-glucan synthase, reducing echinocandin binding and catalytic efficiency, leading resistance | 2 |