Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| P272L | ERG3 | C. dubliniensis | Validated | Heterologous expression in Saccharomyces cerevisiae | 12878500 |
P272L mutation disrupts sterol C5,6-desaturase function, preventing ergosterol synthesis, conferring itraconazole resistance | 2 |