Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| P230L | ERG11 | C. albicans | Validated | Northern Blot and Real-Time PCR Analysis | 14657086 |
The P230L mutation disrupts posaconazole and itraconazole binding to the Erg11 enzyme by altering hydrophobic interactions in the drug-binding pocket, leading to reduced azole susceptibility. | 2 |