Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| N977K | TAC1 | C. albicans | Validated | Gene expression analysis | 19089303 |
N977K mutation hyperactivates Tac1p, upregulating CDR1, CDR2, and PDR17, decreasing drug accumulation, and causing multidrug resistance | 2 |