Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| N977D | TAC1 | C. albicans | Validated | Gene expression profiling; Chromatin immunoprecipitation (ChIP) assay; RT-qPCR | 17905926 28461316 30629653 |
N977D mutation is a gain-of-function mutation that constitutively activates Tac1p, upregulating CDR1 and CDR2, increasing azole efflux, and causing resistance. | 2 |