Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| N972D | TAC1 | C. albicans | Validated | Gene expression profiling; RT-qPCR | 17905926 |
N972D mutation is a gain-of-function mutation that constitutively activates Tac1p, upregulating CDR1 and CDR2, increasing azole efflux causing resistance. | 2 |