Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| N768D | PDR1 | C. glabrata | Validated | Comparative Analysis; Gene expression analysis | 30658200 |
The N768D mutation causes overexpression of multidrug transporters, which pump azoles out of the cell, directly contributing to azole resistance. | 2 |