Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| N740D | TAC1 | C. albicans | Validated | Northern Blotting; Protein Expression | 20876623 30629653 |
The N740D mutation in Tac1p enhances its activity, upregulating CDR1/CDR2 efflux pumps in Candida albicans, reducing intracellular azole concentration and increasing resistance. | 2 |