Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| N535I | CDR1 | C. albicans | Validated | ATPase Activity Assay | 30348662 |
N535I mutation alters efflux pump conformation, reducing fluconazole and cycloheximide transport while conferring FK506 resistance | 2 |