Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| L998F | MRR1 | C. albicans | Validated | MDR1 promoter activation | 18577180 |
L998F mutation causes constitutive overexpression of the MDR1 gene, leading to increased efflux pump activity conferring resistance. | 2 |