Association of mutation to drug resistance
| Mutation | Gene | Species | Validation status | Validation technique(s) | Validation reference(s) | Resistance mechanism(s) | Validation score |
|---|---|---|---|---|---|---|---|
| L962-N969del | TAC1 | C. albicans | Validated | Site-directed mutagenesis | 17693596 17905926 |
L962-N969 deletion is a gain-of-function mutation that constitutively activates Tac1p, upregulating CDR1 and CDR2, increasing azole efflux causing resistance. | 2 |